Among the three isoforms of SIK family [namely, salt‐inducible kinase (SIK)1, SIK2 and SIK3], SIK2 is of particular interest due to involvement in several major signaling pathways such as the PI3K‐AKT‐mechanistic target of rapamycin (mTOR) pathway, the LKB1‐HDAC axis, the Hippo‐YAP pathway and the cAMP‐PKA axis, all of which are related to tumorigenesis and tumor progression [8]. The gene discussed is AKT1; the disease is neoplasm.