Although it is not clear whether the increase in β‐catenin is the sole factor that determines the invasive phenotype due to loss of SIK2 or whether there are additional pathways involved, the results of this study implicate SIK2 as mediating β‐catenin expression and function via the AKT/GSK‐3β signaling pathway in GC cells. The gene discussed is SIK2; the disease is gastric cancer.