Furthermore, no association was revealed between NfL and S100B in SLE patients (B 0.001, 95% CI − 0.003–0.006, p = 0.59), or in the pSS patients (B 0.001, 95% CI − 0.001–0.003, p = 0.56). The gene discussed is NEFL; the disease is systemic lupus erythematosus.