In a multivariable regression model with logNfL as response variable, age as adjustment variable, and sex, aPL in blood, and anti-NR2-, anti-P antibodies, S100 B, TWEAK and IgG in CSF as explanatory variables, increasing levels of anti-NR2 antibodies were associated with increasing levels of NfL in the SLE patients (B 1.27, 95% CI 0.88–1.65, p < 0.001). The gene discussed is NEFL; the disease is systemic lupus erythematosus.