No associations were revealed between anti-NR2 antibodies in blood and NfL in CSF in SLE (B − 0.11, 95% CI − 0.45–0.23, p = 0.53) or pSS patients (B 0.09, 95% CI − 0.16–0.34, p = 0.48). Here, NEFL is linked to systemic lupus erythematosus.