As HIF-1α induces the expression of genes related with tumor survival, we assessed the mRNA levels of CCND2, VEGF, BNIP3L, and CA9, and found that CCND2, VEGF, BNIP3L, and CA9 were upregulated when spheroids were treated with OA, whereas their mRNA levels decreased upon FABP5 or HIF-1α silencing (Fig. 6g). The gene discussed is CA9; the disease is neoplasm.