PAH and hypertensive disorder: Some of the DEGs have been previously associated with the development of hypertension, including Slc9A331 (solute carrier family 9 member A3; fold change = 4.55), Hpgd32 (hydroxyprostaglandin dehydrogenase; fold change = 2.56), Pah7,30 (phenylalanine hydroxylase; fold change = 2.10), Fgf733 (fibroblast growth factor 7; fold change = 2.05) and Cyp2e134 (cytochrome p450, family 2, subfamily e1; fold change = − 2.03) 7,34,35.