ESR1 and breast neoplasm: Similarly, hallmark gene sets associated with the PI3K/AKT pathway, such as “PI3K_AKT_MTOR_SIGNALING” and “MTORC1_SIGNALING”, were enriched in METABRIC ER+/HER2− breast tumors with PRR11 gain or amplification compared to PRR11 deleted/diploid tumors (Fig. 6c).