We then computed the connectivity map (CMap) scores40 with the list of genes significantly upregulated in ER+/HER2− breast cancers with PRR11 gain or amplification vs. diploid/deletion in METABRIC, and in ER+ breast cancers with PRR11 amplification vs. no amplification in TCGA (Top 150 genes, FDR < 0.05). This evidence concerns the gene ESR1 and breast cancer.