This study presented the role of a dysbiotic oral microbiota in the development of a reduced salivary flow rate and FLS in Nfkbiz−/− mice, a model for SS: while the noncohoused Nfkbiz−/− mice developed dysbiosis of the oral microbiota and a salivary gland phenotype, synchronization of the oral microbiota toward that of Nfkbiz+/+ mice through cohousing ameliorated the phenotype. The gene discussed is NFKBIZ; the disease is synovial sarcoma.