MAPT and tauopathy: 50). The accumulation of tau aggregates in the cytosol in L66 mice was a feature also observed in JNPL3 mice (P301L mutation). As in our L66 model, the overexpressed mutant tau led to the formation of cytoplasmic tau aggregates, neuronal loss, and motor deficits (21, 51, 52), and is consistent with what is observed in tauopathies (for review see Ref. 53).