Induction of tumor necrosis-stimulated gene 6 (TSG-6) in the peri-infarct region was observed in ischemic stroke patients (17), as was the irreversible complex formation between the heavy chain of bikunin and HA oligosaccharide (37) mediated by TSG-6 promotes leukocyte adhesion (38). The gene discussed is AMBP; the disease is ischemic stroke.