Because HPSE protein levels increased in vascular cells 24 h post stroke induction (Fig. 2), the impact of glycocalyx protection on the infarct volume was next examined using low-molecular-weight heparin (LMWH: enoxaparin) as an inhibitor of HPSE (20) and low-molecular-weight CS (pLMWCS) as an HYAL1 inhibitor. Here, HPSE is linked to Stroke.