It is worth mentioning that inhibiting the mitochondrial localization of TDP-43 can block its toxicity [17, 30], suggesting that the removal of abnormally aggregated TDP-43 and dysfunctional or damaged mitochondria, and blocking the interaction between TDP-43 and mitochondria may be an effective way to treat neurodegenerative diseases. Here, TARDBP is linked to neurodegenerative disease.