In addition, Bartak et al. confirmed previous published findings by showing that 87% (13/15) of the colonic tumor tissues had promoter hypermethylation in SDC2 gene by bisulfite pyrosequencing and detected its methylation in 89% of CRC in plasma specimens, a sensitivity similar to that from Oh et al. (87%) in serum samples and ours (84%) in stools [24, 25, 27]. Here, SDC2 is linked to colonic neoplasm.