In The Cancer Genome Atlas (TCGA) database, profiling data on a total of 45 pairs of CRC tumor tissues and adjacent normal epithelia by Infinium Human Methylation 450 K Beadchip arrays (Illumina, San Diego, CA) revealed that hypermethylation in SDC2 promoter region occurred in 93% (42/45) of the tumor tissues (unpublished data). The gene discussed is SDC2; the disease is cancer.