SPHK1 and colonic neoplasm: A volcano map (Fig. 1a), boxplots (Fig. 1b), and a heatmap (Fig. 1c) indicated that 20 ARGs (BCL2, CAPN2, CCR2, CDKN1A, FAS, FKBP1B, GABARAP, HSPB8, ITPR1, MAP1LC3C, NKX2-3, NRG1, NRG2, NRG3, PINK1, PRKN, SESN2, TMEM74, TNFSF10, and TP53INP2) were downregulated while 16 ARGs (ATG9B, ATIC, BCL2L1, BID, BIRC5, CAPN10, CD46, CDKN2A, EIF4EBP1, ERO1A, HSP90AB1, IFNG, MYC, SPHK1, TP73, and VEGFA) were overexpressed in colon tumor tissues.