A volcano map (Fig. 1a), boxplots (Fig. 1b), and a heatmap (Fig. 1c) indicated that 20 ARGs (BCL2, CAPN2, CCR2, CDKN1A, FAS, FKBP1B, GABARAP, HSPB8, ITPR1, MAP1LC3C, NKX2-3, NRG1, NRG2, NRG3, PINK1, PRKN, SESN2, TMEM74, TNFSF10, and TP53INP2) were downregulated while 16 ARGs (ATG9B, ATIC, BCL2L1, BID, BIRC5, CAPN10, CD46, CDKN2A, EIF4EBP1, ERO1A, HSP90AB1, IFNG, MYC, SPHK1, TP73, and VEGFA) were overexpressed in colon tumor tissues. This evidence concerns the gene HSPB8 and colonic neoplasm.