Regarding to the fact that IBD is an inflammatory disease and Metrnl anti-inflammatory activities, in this study, the levels of Metrnl in serum were examined in the patients with inflammatory bowel disease and also its association was assessed with the hall-markers of inflammatory cytokines, interleukin (IL)-6, and Tumor necrosis factor (TNF-α). This evidence concerns the gene IL6 and inflammatory bowel disease.