Thus, these data suggest that the activation of the α7nAChR with agonists, such as GTS-21 or nicotine, may represent a pharmacological approach to combat Gram-negative bacterial infections in organisms subjected to oxidative stress (Entezari et al. 2012; Wang 1999; Ogawa et al. 2006; Rowe et al. 2008). The gene discussed is CHRNA7; the disease is gram-negative bacterial infections.