Inspired by the disease classification in KEGG, specifically, one disease like GM2 gangliosidoses or lysosomal cysteine protease deficiencies can belong to two categories, we refine the disease classification by making the 2 CATG-16 diseases belong to both CATG-16 and CATG-10. This evidence concerns the gene CTSB and hyperinsulinemic hypoglycemia, familial, 4.