Non-targeted immune effects of chemotherapy include the elimination of many tumor-activated immunosuppressive mechanisms mediated by immunosuppressive cytokines such as TGFβ1, inhibitory receptors such as CTLA-4, PD-1, and immune cells with immunosuppressive or tolerogenic functions such as Treg, MDSC, and M2 polarized macrophages [25]. This evidence concerns the gene TGFB1 and neoplasm.