TP53 and metastatic colorectal cancer: Ganoderma lucidum is one of the most studied species of medicinal mushrooms, and its dose-dependent induction of apoptosis in SW620 metastatic colorectal cancer cells is the consequence of caspase-3, Bax and p53 activation, with simultaneous inhibition of Bcl-2 expression at mRNA and XIAP at the protein level [45].