Direct antitumor effects are the result of dysregulation of important pathways, such as nuclear factor-kappa B (NF-κB), mitogen activated protein kinase pathway (MAPK), Akt, Wnt, Notch, p53, TGFβ, MMPs, VEGF and others, involved in tumor development and progression [18]. The gene discussed is VEGFA; the disease is neoplasm.