EZH2 directly suppresses the pro-apoptotic genes ID1, ID2, SOX2, and SORL1 [85] and some epithelial tumor suppressor genes such as CDH1, EMP1, VCAN, EPHB2, and ENPP1. This decreases MM cell adhesion capacity and alters their morphology, suggesting that EZH2 might be involved in MM cell dissemination mechanisms [92]. This evidence concerns the gene ID2 and Miyoshi myopathy.