It is important to note that, to date, sensitivity to EZH2 inhibition is not predicted by the extent of H3K27me3 reduction after treatment, by the initial EZH2 expression level, or by the mutational status of UTX, the main H3K27 demethylase, although UTX loss sensitizes MM cells to this inhibition [93]. The gene discussed is KDM6A; the disease is Miyoshi myopathy.