RHOB and neoplasm: While some of these genes are silenced in other tumor types as well, those that may be specific to EBVaGCs, including RHOB, CAMK2N1 and BMP4. It is clear that EBV-induced hypermethylation of the host genome results in silencing of key TSGs and that increased genome-wide methylation results in the silencing of some factors that are typically not affected in other tumor types.