Specifically, this altered ratio was found to increase the odds of developing hormone receptor positive (estrogen receptor [ER] positive, or progesterone receptor [PR] positive, and human epidermal growth factor receptor 2 negative) cancers (OR = 2.03; 95%CI 1.33–3.10), and triple negative cancers (OR = 4.05;95%CI 1.63–10.04); although the confidence intervals were large [59]. The gene discussed is ESR1; the disease is cancer.