In fact, expression of UNC5A, UNC5B and UNC5C is frequently downregulated in colorectal cancer (CRC) and their silencing has been associated in part with loss of heterozygoty (LOH) within UNC5 loci and with epigenetic alterations that are not fully understood [6,7,8,9,10]. This evidence concerns the gene UNC5A and colorectal carcinoma.