In contrast, our results showed a marked decrease in the level of UNC5A, UNC5B and UNC5C transcripts in the colon of AOM/DSS treated mice fed HCD (Figure 2A, compare ND or ND + AOM/DSS vs. HCD + AOM/DSS) strongly suggesting that nutrition is involved in the epigenetic downregulation of these genes that might occur during the progression of CRC. This evidence concerns the gene UNC5B and infectious otitis media.