TP53 and cancer: However, in an elegant paper, Paradisi et al. demonstrated, in a variety of cancer cell lines, that doxorubicin, 5-fluorouracil, paclitaxel and cisplatin treatments induced not only an increase of UNC5 receptors but also a concomitant p53-dependent increase of Netrin-1 thus preventing the pro-apoptotic action of UNC5 receptors [43].