However, and in an inverse correlation with the O-GlcNAcylation levels, our results show that subjecting mice to the High Carbohydrate Diet is sufficient to decrease the expression of UNC5A but not of the other members of the UNC5 family in non-tumorigenic mice colons (Figure 2A, compare ND vs. HCD) and that this decrease in UNC5A transcripts is even greater in mice treated with AOM/DSS and subjected to the HCD (Figure 2A, compare HCD vs. HCD + AOM/DSS). The gene discussed is UNC5A; the disease is infectious otitis media.