In contrast, our results showed a marked decrease in the level of UNC5A, UNC5B and UNC5C transcripts in the colon of AOM/DSS treated mice fed HCD (Figure 2A, compare ND or ND + AOM/DSS vs. HCD + AOM/DSS) strongly suggesting that nutrition is involved in the epigenetic downregulation of these genes that might occur during the progression of CRC. Here, UNC5C is linked to infectious otitis media.