Animals injected with Id1-depleted Lacun3 cells and treated with anti-PD-1 agent experienced a significant tumor growth impairment (Id1sh/DPBS n.s; pLKOsc/anti-PD-1 p = 0.0037; pLKOsc/DPBS p = 0.0174) (Figure 2D,E). The gene discussed is ID1; the disease is neoplasm.