TNF and neoplasm: Cytokines such as Interleukin 6 (IL-6), Tumor Necrosis Factor alpha (TNF-α), Interleukin- 1β (IL-1β) and Interleukin 10 (IL-10), which are released peripherally and in the tumor microenvironment, can act locally in reciprocal signaling interactions [5,11,13,14,15,16].