EGFR and metastatic malignant neoplasm in the lymph nodes: We next divided male LADC patients into WT and mutant EGFR groups and observed that 60 patients who harbored at least one polymorphic T allele of TIMP-3 rs9862 had enhanced risks of developing advanced stage tumors (stage III/IV; OR: 4.047; 95% CI: 1.136–14.411, p = 0.025) and lymph node metastasis (OR: 3.500; 95% CI: 1.003–12.216, p = 0.043) (Table 6).