Mechanistically, in HepG2 and Hep3B HCC cell lines, overexpression of long non-coding RNA LINC00961 was proportionally correlated with CRLS1 mRNA and protein overexpression, resulting in the inhibition of HCC progression (i.e., inhibition of cell proliferation, migration, and invasion in HCC cells). The gene discussed is CRLS1; the disease is hepatocellular carcinoma.