In MAFLD rat models, treatment with active vitamin D reduced liver inflammation and oxidative stress by inhibiting the p53-p21 signaling pathway and associated cell senescence [26]; vitamin D also protected against high fat diet-induced fatty liver by promoting the nuclear translocation of the anti-oxidant molecule nuclear factor erythroid 2-related factor 2 (NFE2L2) [27], decreasing toll-like receptors [28] or repressing sirtuin [29]. This evidence concerns the gene NFE2L2 and fatty liver disease.