Outcome measures were changes of (i) hepatic fat content, as estimated by abdomen ultrasound (US), magnetic resonance imaging (MRI), magnetic resonance spectroscopy (MRS), and liver biopsy; and (ii) hepatic enzymes (aspartate aminotransferase (AST), alanine aminotransferase (ALT), and gamma glutamyl transpeptidase (GGT)), fibrosis markers and scores (cytokeratin-18 (CK-18), procollagen III amino terminal propeptide (PIIINP), Fibrosis-4 Index for Liver Fibrosis (FIB-4), and Enhanced Liver Fibrosis (ELF) score). This evidence concerns the gene KRT18 and Hepatic fibrosis.