We also describe a novel PSS female patient (Decipher 286390) and the third smallest de novo 11p11.2 microdeletion spanning PHF21A (Decipher 415213) in a male with developmental delay (DD), intellectual disability (ID), café-au-lait spots, liner postnatal overgrowth, and West-like pharmacoresistant epilepsy. This evidence concerns the gene PHF21A and Intellectual disability.