We showed that systematic treatment of 19,20-EDP (dose = 0.05 mg/kg/day), which was stabilized by the coadministration of a soluble epoxide hydrolase (sEH) inhibitor, inhibited tumor growth in a Met-1 breast tumor model in FVB mice and attenuated lung tumor metastasis in a Lewis lung carcinoma (LLC)-derived lung metastasis model in C57BL/6 mice [103]. Here, EPHX2 is linked to neoplasm.