Our data showed that cardiovascular disease (CVD) was more frequent in patients with more severe forms of SARS-CoV-2 infection, which could be explained by ACE2 involvement; CVD is associated with higher age and CV risk factor prevalence, thereby triggering RAS activation with ACE/ACE2 disequilibrium alongside downregulation of ACE2 by SARS-CoV-2 infection. This evidence concerns the gene ACE and cardiovascular disorder.