CREB1 and central nervous system cancer: Figure 1C displays the clinical outcome of about 8000 patients who, classified by tumor types, have been further separated into two subcategories (Low and High expression levels) based on CREB mRNA content. While the obtained results disclose a worse CREB-related prognosis in several types of cancer, such as endometrial, glioma, liver, melanoma, prostate, renal and stomach, an inverse correlation comes to light exclusively for colorectal cancer where it seems that a high CREB expression improves the related OS (Figure 1C).