They examined the SNO-MLP level in myocardial samples acquired from patients diagnosed with myocardial hypertrophy, transverse aortic constriction (TAC) mice, angiotensin II/phenylephrine-treated neonatal rat cardiomyocytes, and TLR3 (Toll-like receptor 3) knockout mice. The gene discussed is TLR3; the disease is cardiac hypertrophy.