CSWS has been described in various genetic conditions, including common epilepsy-related ion channel genes like SCN2A or KCNQ2, as well as the N-methyl D-aspartate receptor subunit gene GRIN2A, that show overlapping expression at neuronal synapses [28,29]. This evidence concerns the gene SCN2A and developmental and/or epileptic encephalopathy with spike-wave activation in sleep.