In addition to Foxp3 mutations, deficiency in other regulators of Treg-suppressive functions, such as TRAF3 [203], CD28 [204], Id2/Id3 [205], Ubc13 [206], Ndfip1 [207], NF-κB p65 [208], Helios [209], Th-POK/LRF [210], EZH2 [211], BACH2 [212,213], SATB1 [214], IRF-4 and Blimp-1 [215], and LKB1 [216], can also result in severe autoimmune diseases, although most of these studies were carried out in mice, and their relevance in human diseases remains to be tested. Here, FOXP3 is linked to autoimmune disease.