nSMase1 is located in the reticulum endoplasmic/Golgi apparatus and in the cell nucleus and it was involved in apoptosis and cancer; nSMase2 is specific of the plasma membrane and it was involved in exosome formation, and in the inflammatory response; nSMase3 is located in endoplasmic reticulum and it was involved in cellular stress response; nSMase4 belongs to the mitochondria and its function is not yet clear in human cells [25]. The gene discussed is SMPD2; the disease is cancer.