IRPs are activated by iron deficiency and bind iron-responsive element (IRE) present in the 5′ or 3′ untranslated regions (UTRs) of numerous mRNAs encoding proteins for iron metabolism, like TFR1, DMT1, FPN, FTs subunits (FTH1 and FTL). This evidence concerns the gene SLC40A1 and Iron deficiency anemia.