The role of the KKS in the pathogenesis of hypertension has been studied by (1) measuring various components of the system, (2) examining bradykinin B2 receptor antagonists, (3) studying mice with B1, B2, or both deleted by homologous recombination, (4) the deletion of the tissue kallikrein gene, and (5) observing rats deficient in kininogen. Here, KNG1 is linked to Hypertension.