In mineralocorticoid hypertension, where KKS and ACE activity are reportedly increased [180], chronic ACE inhibitors have a small but significant antihypertensive effect that can be blunted by blocking the B2 receptor with icatibant [111,181], suggesting that kinins may be involved; however, they are ineffective in SHR [179] or hypertension that is induced by aortic coarctation [114,161,182]. The gene discussed is ACE; the disease is hypertensive disorder.