APOD, APOE, BCHE, DBH, GGH, GSN, ITIH3, LCN2, MMP2, PHOX2B, PON1, TNXB, VWF, YWHAE, 14 of these proteins were found to be associated with psychiatric symptoms, such as schizophrenia, bipolar disorder, cocaine use disorders, substance-induced psychosis, alcohol use disorders, and depression. The gene discussed is APOE; the disease is depressive disorder.