WWTR1 and neoplasm: Thus, beyond a contribution of VEGFR-dependent YAP/TAZ activation in endothelial cells to tumour angiogenesis, an attractive hypothesis is that YAP/TAZ activation downstream from VEGFR in tumour cells themselves would foster vasculogenic mimicry, a process whereby tumour cells promote the formation of microvascular channels to supply blood into the tumour independently from endothelial cells [88].