Based on the various potential upstream activators of YAP/TAZ in CMS4 CRC, we may further surmise that if YAP/TAZ are activated in some way and co-operate with the adequate partner, colon cancers gain CMS4 properties and that the high activation of YAP/TAZ is essential to maintain CMS4 phenotype. This evidence concerns the gene WWTR1 and colorectal carcinoma.