A recurrent observation is that the knockdown of YAP and/or TAZ inhibits the proliferation of CRC cells [23,46,47,48], their growth in soft agar [16,29,44], migration [49], invasion [50], CSC-like attributes [51,52] or tumorigenic properties in xenograft experiments [16,44,47,53,54]. Here, WWTR1 is linked to colorectal carcinoma.