Regarding goiter, super physiological doses of L-triiodothyronine given every other day aiming to suppress TSH can reduce the size of the gland and the effective level of TSH suppression is assessed by the suppression of serum Tg.[19] THRS patients with hypothyroidism should be treated with TH starting with a small dose and gradually increasing the dose. This evidence concerns the gene TG and hypothyroidism.