Indeed, anticoagulants and antiplatelet agents are equally valid for the secondary prophylaxis of stroke due to cervical artery dissection.[16] Meanwhile, case series studies reported that intravenous recombinant tissue plasminogen activator may be effective and safe in patients with carotid artery dissection.[1–3] Intervention or surgical operation should be considered in case of persistent pseudoaneurysm, or in patients who remain symptomatic due to thromboembolic events or show symptom progression despite anticoagulation treatment.[17]. This evidence concerns the gene PLAT and carotid artery dissection.