Causative TP63 mutations have been identified in 6 different syndromes: ectrodactyly ectodermal dysplasia-cleft lip/palate (EEC) syndrome, acro-dermato-ungual-lacrimal-tooth (ADULT) syndrome, limb-mammary syndrome (LMS), ankyloblepharon-ectodermal dysplasia-clefting (AEC) syndrome, Rapp–Hodgkin syndrome (RHS), and nonsyndromic split-hand/split-foot malformation (SHFM). Here, TP63 is linked to EEC syndrome.