EEC syndrome, LMS, and ADULT syndrome have traits along the same clinical spectrum and a similar pattern of p63 mutations; thus, the concept of ELA (EEC-ADULT-LM) syndrome has been reported to simplify the classification of TP63-associated disorders.[4] In the present article, a case of R319H (described as R280H) mutation in TP63 with ectrodactyly, syndactyly, and tooth anomaly, is reported, and the correlation between genotype and phenotype is discussed based on the current case and previous literature. Here, TP63 is linked to EEC syndrome.