TP63 and neoplasm: Ectrodactyly or split hand/foot malformation is a rare congenital limb disorder with a prevalence of approximately 1 in 18,000 newborns.[1] TP63, a member of the p53 gene family and a major tumor suppressor gene, is highly expressed in embryonic ectoderm tissues in adults.[2] TP63 acts as a key regulator in limb development and other tissues, including epithelial and craniofacial tissues, not classical tumor-suppressor genes.[3] Hence, ectrodactyly sometimes occurs along with other symptoms.