FTH1 and hyperinsulinemic hypoglycemia, familial, 4: Having established that IFN-I signaling modulated Fe metabolism specifically within myeloid progenitors to induce necrosis, we next investigated whether disruption of Fe metabolism, using an inducible mouse model of ferritin H chain (FTH) deficiency (Blankenhaus et al., 2019), dysregulated hematopoiesis and/or trained immunity after Mtb infection.