Given the importance of ACE2 and TMPRSS2 in regard to SARS-CoV-2 infection and the relationship between CKD and COVID-19 severity, we compared tubulointerstitial and glomerular expression of ACE2 and TMPRSS2 in healthy living donors (HLD) and subjects with CKD from the publicly available European Renal cDNA Bank (ERCB; nephroseq.org, University of Michigan, Ann Arbor, MI). The gene discussed is TMPRSS2; the disease is COVID-19.