In kidneys of mice with ischemia-reperfusion injury or unilateral ureteral obstruction, the loss of ACE2 exacerbated infiltration of neutrophils, F4/80+ macrophages, and CD3+ T cells, and increased mRNA levels of cytokines and chemokines, including IL6, TNF, and MCP-1 [35, 36]. This evidence concerns the gene TNF and Ureteral obstruction.