For example (1) Enterococcus faecium significantly decreased body weight, serum lipid levels, blood glucose level, and insulin resistance in rats fed with a high-fat diet [47]; (2) several Lactococcus lactis strains have shown the ability to reduce hyperglycemia, improve glucose tolerance and insulin secretion [48, 49]; (3) bacteria from Odoribacter genus have been associated with a healthy fasting serum lipid profile [26], and displayed a negative correlation with insulin resistance [50]. The gene discussed is INS; the disease is Insulin resistance.