Furthermore, the negative correlation between the highest levels of TGFB1 mRNA expression levels and low intrahepatic IL10 mRNA expression levels in the livers of individuals with HCV demonstrates that chronically infected patients have decreased IL-10 levels with the continuous stimulation of factors that lead to the synthesis of TGF-β1, with the consequent progression of fibrosis and evolution to cirrhosis, corroborating previous studies [30, 31]. This evidence concerns the gene TGFB1 and Cirrhosis.