The same trend was observed with respect to necroinflammatory activity, in which TGFB1 expression was significantly lower in patients without liver inflammation (A0) (median mRNA: 8.990; IQR: 4.860) than in those with mild (A1) (median mRNA: 12.05; IQR: 15.520) and moderate (A2) (median mRNA: 12.712; IQR: 7.031) necroinflammatory activity (p = 0.0199 and p = 0.0177, respectively; Fig 5B). This evidence concerns the gene TGFB1 and Hepatitis.