When including CXCL12 serum levels in a multivariate Cox regression model, the relationship between CXCL12 and ADA risk was still significant (aHR = 2.329 [1.106–4.90]), as well as the relationship between ADA occurrence and antibiotics (aHR = 0.243 [0.072–0.819]) and infections (aHR = 2.867 [1.281–6.415]), whereas relationships with tobacco (aHR = 1.583 [0.532–4.710], p = 0.41) and immunosuppressants (aHR = 0.889 [0.387–2.040], p = 0.78) did not reach statistical significance. This evidence concerns the gene CXCL12 and infection.