AMD3100 in combination with G-CSF, anti-CD20 and IL2/anti-IL2 mAb (monoclonal Antibody) complexes has been tested as a treatment to induce tolerance in a mouse model of hemophilia A with ADAs against Factor VIII, and it achieved a successful stable reduction of long-lived ADA-producing plasma cells and of ADA titers [41]. This evidence concerns the gene AGPS and hemophilia A.