One of our SCAD cases has 2 heterozygous variants in YY1AP1. Homozygous or compound heterozygous protein-truncating variants (PTVs) in YY1AP1 can cause Grange syndrome, which is characterized by severe, early-onset vaso-occlusive disease and FMD-like vascular features, brachydactyly, syndactyly, fragile bones, and learning disabilities14; however, we have been unable to phase the 2 heterozygous YY1AP1 PTVs in the patient. This evidence concerns the gene YY1AP1 and grange syndrome.