The population prevalence of PKD2 disease variants is also lower than for PKD1. 25–27 Gene-set analysis identified Loop of Henle development genes, driven by individuals with QVs in PKD1, UMOD, HES5, and DLL1, suggesting that the association between SCAD events and renal dysfunction may be more extensive than has been recognized. This evidence concerns the gene PKD1 and Abnormal renal physiology.