The final pooled data suggested that POLE driver mutations occurred more frequently in male patients (Asian vs. Non‐Asian: 78.90% vs. 74.60%; p = 1.00) and at early stages (Stage 0–II) of CRC (Asian vs. Non‐Asian: 78.90% vs. 73.30%; p = 0.73). This evidence concerns the gene POLE and colorectal carcinoma.