Mice deficient in IL-1 receptor signaling are far more susceptible to TB than Casp1−/− (actually Casp1−/−Casp11−/−; Kayagaki et al., 2011; Kuida et al., 1995) and Asc−/− mice are, suggesting a role for caspase-1– and caspase-11–independent IL-1β production and arguing against the importance of pyroptosis in TB (Dorhoi et al., 2012; Mayer-Barber et al., 2010). The gene discussed is CASP1; the disease is tuberculosis.