Using a mouse model of asthma induced by OVA, we found that DEK was overexpressed in lung sections of asthmatic mice and that DTA‐64 (single‐stranded DNA aptamers targeting DEK) significantly reduced airway remodelling, including infiltration of inflammatory cells, airway mucus production, goblet cell proliferation, BALF TGF‐β1 expression, serum IgE, AHR and EMT. This evidence concerns the gene IGHE and asthma.