The CdcD protein (cdcD), orthologue of VCP/p97 in humans, is related with cell death by autophagy in the presence of aberrant mitochondria and has been linked to IBMPFD (inclusion body myopathy with early onset Paget's disease of bone and frontotemporal dementia), HSP (hereditary spastic paraplegia), and a form of ALS (amyotrophic lateral sclerosis) (Annesley et al., 2014). The gene discussed is VCP; the disease is bone Paget disease.