Formal analysis of quality of life (using the Health-related Quality of Life in Children PedsQLTM 4.0 measurement model [66]) has been completed with 137 children, and a review of clinical health outcomes on a cohort of 81 children at NHP over the age of 10 years includes measures of growth, body mass index, insulin levels, HOMA-IR (homeostatic model assessment of insulin resistance) and metabolic syndrome criteria [63]. Here, INS is linked to metabolic syndrome.